Description of service

BPRC will offer access to its library of human cell reporter assays for the identification of innate immune receptor- induced signalling cascades, including human cell lines transfected with PAMPs such as TLR and/or engineered to express luciferase in response to NF-kB or IFRE-mediated signal transduction, and cell lines that provide insight into the intracellular signalling cascades of innate immune receptors. These lines allow for qualitative and quantitative assessment of innate immune responses provoked by different stimuli. The combined use of the aforementioned cell-line based assays in a tiered testing strategy provides rapid, detailed, robust and quantitative information about the innate immune responses that are induced by vaccines, adjuvants or components thereof, resulting in innate immune response fingerprints