Description of service
PHE will provide access to the ferret model of influenza at BSL2 as part of TNA8 Animal models platform.
12 weeks, maximum study duration
3-4 months of advance notice required before start of study
Services do NOT include
Optional: additional groups of ferrets for lung/tissues; virus neutralisation titres; histopathology; immunogenicity studies.
Report detailing clinical parameters of disease, virology (nasal wash virus titres), serology, IFN-gamma ELISA, IFN-gamma Elispot.
Sample Requirements - input of users
User to provide vaccine samples of suitable purity and quality for vaccination of ferrets. Documentation should be provided confirming quality control (freedom from pyrogens, freedom from bacterial contamination). User to provide antigen for immunological assays if require
Immunogenicity and chanllenge studies in ferrets