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BIOASTER is a non-for-profit technological research institute dedicated to applied microbiology created in 2012 by the French Government. BIOASTER conducts innovative collaborative research, with and for public and private partners in the four major application fields of microbiology including human and veterinary infectious diseases: vaccines, antimicrobials, diagnosis and microbiota. Each applied research project, involving academics, SMEs and industrials partners, is undertaken by a team of high-level scientists and engineers integrating state-of-the-art technological equipment and expertise, dedicated to conceive and to develop new innovative and high value technology solutions. With offices and laboratories in Lyon and Paris (2,500 m² laboratories including biosafety level 2 & 3 labs, BIOASTER has today more than 100 employees including 80 scientists and engineers originating from 16 different countries, involved in collaborative projects.

Role in the TRANSVAC project

The Metabolomics & Proteomics Technology Unit will participate in the WP13 (TNA7) Immuno-correlates and Systems Biology work package of the project. BIOASTER will also participate in the Scientific-technical networking activities of the project.

Main staff involved in TRANSVAC

Frédéric Béquet, PhD in Neurosciences; Xavier Méniche, PhD in Biochemistry; Kristin Hennig, PhD in Chemistry;

The Facility

The Metabolomics & Proteomics Technology Unit activity focuses on the identification of biomarkers and the functional characterization of metabolic pathways, applied to Research & Development of antimicrobials, vaccines, diagnostic tests or probiotics. The activity is based on approaches such as metabolic profiling, fingerprinting, fluxomics, quantitative metabolomics and MS Imaging. The unit is multidisciplinary and includes expertise covering all the value chain of metabolomics and proteomics, from automated sample preparation to data analysis and interpretation, including the development of innovative technologies and new analytical approaches.

TNA or Training provided

The Metabolomics & Proteomics Technology Unit will offer localizomics approaches based on Mass Spectrometry Imaging on tissue/organs slices (or on in-vitro cell cultures), either in targeted MS (e.g. drug and metabolites distribution) or in untargeted high resolution (HR) MS (metabolite profiling). The samples will be analysed on the MS Imaging platform by our qualified personal and the user will receive an image of the metabolite(s) of interest distribution. If needed, histology coloration can also be performed on the same tissue sample. For untargeted approaches, a list of relevant discriminant metabolites will be provided. Applied training in Mass Spectrometry Imaging, based on the DESI technology, will also be proposed.






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