Role in the TRANSVAC project
The role of LSHTM in the TRANSVAC2 project is to develop a sensitive human whole-blood assay to compare the potency of whole vaccines and vaccine antigens based on their ability to induce innate and adaptive cytokine and chemokine responses. These responses will be quantified using both commercial and customised Luminex bead arrays. Once developed, the assays will be used to analyse in vitro cytokine and chemokine induction, e.g. to compare different versions of a vaccine, or the same vaccine produced in different host cells, or different batches of a vaccine to demonstrate batch-to-batch reproducibility. Transnational access to this assay will then be provided.