Webminar on Structural vaccinology approach
The comprehension of the recognition pattern and mode of interaction between antigen and antibody is an essential aspect for vaccine rational design and optimisation. To reach this goal structural characterisation is necessary as it would provide a detailed description of the conformational properties of the epitopes and of their interaction patterns with antibodies. A few examples of the application of the presented approach, i.e. Structural Vaccinology, for the optimisation of vaccines will be presented.
Prof. Lucia Banci
Lucia Banci (Professor of Chemistry at the University of Florence) - recognised as a world class leader in the characterisation of functional processes in a cellular context with atomic resolution. Her work integrates structural, interaction and dynamical information with thermodynamic properties, particularly in metal ion trafficking in the cell. Her structural characterisation of pathogen variants led to the design of a chimeric vaccine antigen that affords complete protection against all variants of meningococcus B.