Course content

A list of the course contents is given on the General strategies in process development for recombinant protein production and purification in different host systems with a special focus  on state of the art methods to improve down-stream process development by implementing design of experiments and quality by design aspects, e.g. in clarification and chromatographic purification. Typical processes will be discussed using real-life equipment and examples.

Learning Outcomes 

Comprehensive insight into the possibilities to conduct and improve process development and scale-up of biomanufacturing processes.

M11  Process development and scale-up of recombinant protein vaccines

Who should apply

Scientists involved or interested in vaccine R&D and manufacturing projects.

Minimal requirements

Basic understanding of recombinant DNA technology, protein chemistry and typical process unit operations.


Accommodation will be provided. Travel Costs are not included.

Course Goals 

Process development and scale-up of recombinant protein vaccines.


Application Deadline:  

1 July 2021

Course Dates:

Q4 2021 (2 days)


Fraunhofer IME,

Aachen Germany

Participant Nr.: max. 15


Johannes Buyel

This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement N° 730964.

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