TNA or Training provided
Modality of access under this proposal: Users will provide samples and together we will decide the relevant metabolic pathways to target and profile, based on the applicant’s biological question(s). Data analysis of metabolic profiles can be carried out by the users, or supported by the facility. Users can be trained at the facility if needed. Support offered under this TNA: Comprehensive targeted metabolomics profiling based on liquid chromatography – mass spectrometry. Platforms included: Lipid metabolism, Bile acids, Organic acids Central Carbon metabolism, Biogenic amines and amino acids, Acyl-carnitines, Eicosanoids, Endocannabinoids and oxidative stress markers. In agreement with the facility, users will decide the scope of the service, including which platforms are to be used. Samples matrixes suitable for metabolomics analyses include in vitro: cell lysate and medium, and in vivo: Plasma, serum, urine, CSF, micro-dialysate and tissues.