Role in the TRANSVAC project
iBET will be represented by senior experts from its Animal Cell Technology Unit (ACTU). One of the focus areas of the ACTU is rational process development for complex biopharmaceuticals, in particular the production of vaccine candidates (e.g. subunit recombinant proteins, viruses and virus-like particles - VLPs) for human and veterinary use based on insect and mammalian cell lines. These activities have been developed within both EC-funded and industry-funded projects, involving large companies (Novartis, MSD) and small start-ups (LETI, ALLOKSYS, VCN, GENETHON, CEVEC). Competencies include upstream and downstream processing, where IBET has also participated in developing and testing single-use equipment for Sartorius-Stedim Biotech, GE Healthcare, Merck Millipore, PALL and LONZA. iBET will be involved in WP7 (cross-platform screening and optimisation service) and WP10 (pre-clinical GLP production services). In WP7, iBET will be involved in activities connected with mammalian and insect cell expression platform screening, and small-scale production and purification of candidate vaccines. In WP10, iBET will be involved in the GMP-directed evaluation of vaccine candidate production processes, production scale-up for vaccine candidates, definition of specifications for pilot-scale production, product stability testing and delivery for GLP toxicology studies, as well as the evaluation of development, manufacturing and finishing documentation.