Central Veterinary Institute (CVI) of Wageningen UR (former partner ID-Lelystad)

The Central Veterinary Institute (CVI) of Wageningen UR, based in Lelystad the Netherlands, is the national reference laboratory for the Dutch government and an international operating (contract) research organisation with extensive experience in animal studies in laboratory and large (farm) animals and belongs to Wageningen University and Research Centre (WUR). The animal facilities of WUR in Lelystad range from conventional up to and including BSL-3. All animal facilities fulfil the strict criteria on housing of experimental animals and are in compliance with the Dutch law on animal experimentation. The animal facilities comprise approx. 3,000 sq.m. of animal units of different sizes and containment levels. The animal units are constructed as multi-purpose facilities and can house various animal species, ranging from mice to pigs. All containment units are fully equipped to be able to conduct challenge trials with most animal pathogens.

There is extensive experience with pig research for both studies in the veterinary and human biomedical field. Combined with the fully equipped laboratories, this guarantees that well-conducted animal studies can be performed in a consistent and safe way. The facility is committed to ISO 9000:2001 and ISO17025 quality standards. CVI has a broad experience with bacterial (mycobacteria, streptococci, E. Coli) and viral vaccine studies (influenza, (bovine) respiratry syncytial virus porcine/bovine herpes virus) and with pig research. A wide range of techniques and expertise with respect to pig models is available. CVI has extensive expertise on pig research in the field of immunology, microbiology, functional genomics and (immuno) pathology, which are utilised in basic and applied research on vaccines, CVI is a contract research organisation that offers their expertise and facilities to internal (Wageningen UR) and external clients.

Transnational access provided

As a partner of TRANSVAC, CVI will provide access to their animal facilities (Lelystad) to carry out safety and immunogenicity studies of new candidate vaccines and/or of novel vaccination (administration) strategies in pigs, mice (healthy) and guinea pigs. The access will comprise purchase of animals, the housing and animal care and biotechnical expertise for administration and sampling. Scientific support will include advice on experimental design and methodology, documentation of results for all experiments conducted during the project, and appropriate sampling and conservation of samples. In depth laboratory analyses are not included. CVI will also provide the required legal approvals and ethical approval.